Tuesday, June 16, 2009

A Breakthrough in finding Genetic Mutation to Decode Cancers

Genetic Mutation can be defined as , Changes in the nucleotide sequence of the genetic material (i.e. DNA, or RNA, in the case of viruses), which are usually caused by copying errors during replication that further lead to base substitution, insertion, or deletion of one or more base pairs.

A group of Vancouver doctors and scientists is receiving international recognition after making a breakthrough cancer discovery that could lead to new cancer diagnostics and treatments.

The team, which included more than 40 people from the BC Cancer Agency and Vancouver Coastal Health Research Institute, discovered that a single genetic mutation is responsible for granulosa cell tumours, a rare and often untreatable form of ovarian cancer.

The discovery is akin to finding a needle in a haystack, as there are three billion components to the genetic code of the tumour.

But the research, published this week in the New England Journal of Medicine, can be applied to more than ovarian cancer.

State-of-the-art technology used to identify the single mutation in ovarian cancer's DNA can also be used to unravel the genetic sequences of other cancers.

"What we can do is completely decode cancers," said Dr. David Huntsman, a genetic pathologist at the BC Cancer Agency, Vancouver General Hospital and the University of B.C.

"This would have been completely unfathomable two years ago. If you had suggested doing it, people would have looked at you like you had said you were going to fly to the moon without a rocket."

Huntsman said the ability to decode the genetic sequences of specific cancers will be part of a road map to truly personalized medicine, in which doctors will be able to come up with an individualized "recipe" for every patient.

"At some point we have to start recognizing that every patient is different in the way they respond not only to their disease, but the way they respond to and handle the treatment," Huntsman said.


More health news can be found at www.vancouversun.com/health

and the exclusive video for this article is available, click on the following link to get it.
Dr. James Mackay on cancer and genetics

Saturday, June 13, 2009

Indian Politics - A Family Affair

The Indian parliament is full of relatives – more than ever before. Mothers and sons, fathers and sons, fathers and daughters, third-generation stars, wives, widows, in-laws, uncles and nephews. Has democracy become a monarchy by other means?

Over a decade ago, when standards of behaviour in the Indian parliament were nose-diving – what with acrimony, physical demonstrations, unparliamentary language, personal attacks and constant shrill bickering, a perpetual partisan divide and even occasional exchange of physical blows becoming the order of the day – former Bharatiya Janata party (BJP) prime minister Atal Bihari Vajpayee wished that Indian politics would live up to the age-old ideal of vasudhaika kutumbikam ("all the universe is a family"). Today it seems that his wish has come true, and with a vengeance.

The biggest winner of the recent Lok Sabha elections was not the Congress-led United Progressive Alliance (UPA) but rather the dynasty; a belief that democracy is and should be monarchy through other means. Every leader, sans party, beyond ideological divide, beyond left, right or centre, of communalism or secularism, is a votary of family rule, whose parliamentary seats are part of the family's estate.

Relatives thrive in the Indian parliament today. Two mother-son sets, all four from one family – Sonia and Rahul Gandhi and Maneka and Varun Gandhi – from Congress and BJP respectively are divided on every other possible issue but still united in leading the family's hold over political power.

Then there are four father-son sets. Ajit Singh and Jayant Chaudhary (Ajit's father, Charan Singh, was a former prime minister); HD Deve Gowda and HD Kumaraswamy (Gowda is a former prime minister, while his son was chief minister of Karnataka); Mulayam Singh and Akhilesh Yadav (Singh was former defence minister and UP chief minister); and Adhikari Sisir Kumar and Adhikari Suvendu.

In all, 27 MPs in Lok Sabha today belong to prominent political families: sons, daughters, siblings, wives, cousins, nephews – highlighting the Indian political family business power, where parliamentary seats are heirlooms to be passed on.

In contrast, agriculture minister Sharad Pawar – ever a champion of empowering women – has her daughter, Supriya Sule, as a parliamentary colleague, while Farooq Abdullah (former chief minister of Jammu and Kashmir) will share treasury benches with son-in-law Sachin Pilot, and Abdullah's son, Omar Abdullah, rules Jammu and Kashmir as chief minister. Incidentally, Pilot is son of the late Congress leader, Rajesh Pilot.

Another family who can give a run for their money is the Karunanidhis, in Tamil Nadu. Old man Karunanidhi, chief minister at 82, with three wives, has made eldest son Alagiri and nephew Dayanidhi Maran ministers in the central cabinet, while son Stalin was made deputy chief minister in Tamil Nadu and daughter Kanimozhi has to make do with a merely being a member of the Rajya Sabha (Indian parliament).

The fountainhead of this tendency was the reign of three generations of Nehru-Gandhis; Jawaharlal Nehru, his daughter Indira Gandhi and grandson Rajiv Gandhi as prime ministers. While Rajiv's widow, an Italian, Sonia (nee Manio) Gandhi refused prime ministership owing to sustained opposition by the BJP, her son Rahul is waiting to take over the mantle.

Chieftains and warlords have emulated that model across the nation. Some of the great Indian political families include Badals of Punjab, Yadavs in Bihar and Uttar Pradesh, Thackerays and Pawars in Maharashtra, Patnaiks in Orissa and Reddys in Andhra Pradesh.

There have been times when the death of popular leaders like MG Ramachandran or NT Rama Rao led to an open war of succession with widows, mistresses, son-in-laws, sons and second wives all fighting for their legacy. But today, like well managed corporations; families tend to handle their succession in a more orderly way.

A contrasting aspect is some unmarried and family-less leaders who have succeeded in India – Abdul Kalam, Vajpayee, J Jayalalitha, Mayawati, Mamata Benarjee, Narendra Modi – but no one knows if they will remain an exception or even prove to be a dying breed. In any case, they have shown little inclination to take up the cause of institutionalizing merit over family.

Several families, like the Scindias, Thackerays and Nandamuris, have spread across parties. Bal Thackeray's nephew, Raj, broke-up with cousin Udhav after a bitter succession war and started the Maharashtra Navnirman Sena party. Agatha Sangma, a young ministerial face in the Congress-led UPA government, is the daughter of former Lok Sabha Speaker PA Sangma, who led an anti-Sonia campaign. Central minister D Purandareswari, daughter of Telugu Desam party founder NT Rama Rao, and husband D Venkateshwara Rao (Andhra Pradesh state assembly) are with Congress, while her brother-in-law N Chandrababu Naidu and other brothers are in control of the TDP.

The erstwhile royal family of Scindia had the most famous feud of them all, where old mother Rajamate was a key leader of the BJP while her son, Madhavrao, was a senior Congress leader. After their deaths, Madhavrao's son, Jyotiraditya, became part of the Rahul Gandhi brigade in Congress while Madhavrao's sister, Vasundhara Raje, was chief minister of Rajasthan leading the BJP government.

Miera Kumar, the first woman and Dalit to be elected Speaker of Lok Sabha, still would not have made it were she also not daughter of former deputy prime minister Jagjivan Ram.

Family power in politics is nothing new to south Asia, where dynasties like the Gandhis and Bhuttos and Hasinas have held clout for generations. But with family name more important in politics than individual qualities or merits in India, it strikes at the very core of democracy. Grassroots activists and student leaders with no patronage matter little, and given the huge money and muscle power involved in elections, non-family upstarts can only dream of power from the sidelines. In fact, its impact goes beyond politics, with the reign of dynasties extending to most businesses, even Bollywood.

Hail the Great Indian Political Family! Jai Ho!

Friday, June 12, 2009

Child Poverty Due to become Past

Ministers are making it a legal duty for the government, local authorities and other organisations to help to end child poverty across the UK.

The government looks set to miss its own targets on cutting the numbers of children living in poverty.

A new bill being published later will make it a duty to support families so that child poverty is eradicated by 2020, the goal set by Tony Blair.

Campaigners say this means future governments cannot easily drop the aim.

The latest figures available, for 2007/8, put the number of children living in poverty at 2.9 million.

Poverty in this case is measured relatively - those who live in households with an income of less than 60% of the average.

Since Tony Blair set the target of ending child poverty by 2020, the government says it has lifted half a million children out of poverty, down from 3.4 million in 1999.

The then prime minister also set a target to halve the numbers of children in poverty by 2010 - but that looks unlikely to be met.

Ministers say measures taken since the 2007 Budget will move another 500,000 children out of poverty, but that will still leave 2.4 million in that position.

Strategy

Under the Child Poverty Bill, a legal duty to work together to support families to end child poverty will be placed on central government, councils and services including the police, NHS primary care trusts and youth offending agencies.

It requires the Westminster government to publish a UK-wide child poverty strategy, which must be revised every three years.

It also puts the same duty on Scottish and Northern Irish ministers.

It sets out four targets to be met by 2020 across the UK, which the government says will "define the eradication of poverty".

These include having fewer than 10% of children living in relative low income poverty (i.e. in households with less than 60% of average).

The bill will also establish a child poverty commission to advise on strategies to tackle child poverty.

The main ways the government tries to move children's families out of poverty include changes to the tax and benefits system, including tax credits, and a wider approach to raising skills and closing the education achievement gap between rich and poor.

Providing better housing and children's centres such as Sure Start are also part of the drive.

'Big challenge'

Work and Pensions Secretary Yvette Cooper said: "This bill is about giving every child a fair chance in life.

"I want a society where children don't miss out on school trips, aren't stuck in poor housing with no space to do their homework and aren't left behind because they don't have a computer or internet access.

"This is a big challenge, and one which we will not shy away from. It holds current and future government's feet to the flames and won't allow any government to quietly forget about child poverty or walk away."

But Conservative spokeswoman for work and pensions Theresa May said the pledge to halve child poverty by 2010 was "just one of countless Labour promises that lays in tatters".

"It is a tragedy that the number of children falling into the poverty cycle is continuing to rise," she said.

"The government needs to wake up and get a grip of this problem. Simply relying on means-tested benefits to address the symptoms of poverty is unsustainable. Instead we must tackle the root causes of poverty, such as educational failure, family breakdown, drug abuse, indebtedness and crime."

The Child Poverty Action Group said the new bill was a "major step in the fight to end Britian's child poverty shame".

The group's chief executive, Kate Green said: "You rarely see such high levels of child poverty as we have in the UK in other wealthy countries and that is clearly wrong.

"We must stop so many of our children growing up with worse health, poor life chances and a lower life expectancy.

"The bill will mean action on child poverty is no longer optional for future governments, it will be mandatory."

source: BBC News

Thursday, June 11, 2009

Global Climate Change

I have been arguing against man made global warming since I started writing articles. I have not changed my mind one iota and have even become more convinced than ever. This last week, it hit the fan again and the the power of large grants for research again flexed it’s muscle.

NASA administrator, Michael Griffin, told a National Public Radio (NPR) interviewer that he was not sure global warming was something we should be worrying about. He said that he had no doubt that a trend of global warming exists but that he did not believe it was something we should be worried about.

Now, after some of the ones with influence have gotten hold on Mr. Griffin, he has apologized! He has not recanted, only apologized for mentioning it. Read his statement from the Associated Press:

"Unfortunately, this is an issue which has become far more political than technical and it would have been well for me to have stayed out of it."

"All I can really do is apologize to all you guys ... I feel badly that I caused this amount of controversy over something like this," he said

This hit the headlines like a nuclear explosion. I had already read somewhere that NASA had about decided that global warming was indeed a result of the solar activity rather than man.

The atmospheric temperature has been dropping now for a full decade due to the lack of solar activity and most scientists not on the grants payroll, have long since argued that this is simply another of the regular cycles of temperature change. Yet, the "Chicken Little" mentality continues to drive the populace into believing the sky is falling.

Numerous highly ranked scientists have already signed a gigantic petition indicating their opposition to the man-made climate change theory. But those who are under humongous grants for their investigating this natural phenomena keep blistering the public with their stupid theory that a slight increase in carbon dioxide particles are causing it. The tiny increase in the carbon, which is a tiny portion of the atmospheric makeup could never cause such a thing as global warming. They know it. They just want to milk it for all it’s worth and there are plenty of gullible people to yell the sky is falling to give a semblance of credence to their nonsense.

Now, don’t tell me that a large amount of pressure was not put on Mr. Griffin simply because he was being honest. This nation, as most of the other nations of the world, is presently in a financial crunch that may prove to massive from which to recover. Yet, for those who are getting fat from this ruse have taken it so far as to cause us and most of the world, to go even deeper into debt to try and fight off this natural cycling of temperature which has been up and down since any records have been kept. This should be a criminal offense and people, such as Al Gore and other outspoken, jet traveling polluters should be prosecuted for having promulgated this farce.

The U.N. has bought into this charade as a ruse to invoke a world-wide taxation to fight this imaginary enemy. And guess who will carry the burden of taxation? Guess who will be forced to reduce their emissions most of anyone in the world? There is no guessing to do. It is a foregone conclusion that the U.S. Will be expected to carry the load when we are not able to carry our own load. It is time our politicians woke up and paid attention to some of these honest scientists who "slip up" and tell it like it is, only to face the possibility of being cast out of the "society".

This is an Article by: Joel Hendon, Birmingham Biblical Examiner.


Return of the Whale hunters

(video is available at the end of this article)

Killing that which you love is one of the more discomforting human failings; especially when it comes to animals.

As last week's mass stranding on a Cape Town beach demonstrates, whales and dolphins exert a particularly powerful hold on the public imagination.

The 55 false killer whales (not pilot whales, as was widely reported in the press) beached themselves at Kommetjie, floundering helplessly on the sand.

Attempts to save them were hampered by well intentioned amateurs.

Even the humane decision taken to euthanise the animals was threatened by members of the public who insisted on futile efforts to “rescue” the whales.

Nan Rice of the Dolphin Action and Protection organisation told the South African Times: “I think it's disgusting. It makes me sick. You can't be sentimental, you have to be serious.

The public get hysterical and start acting like prima donnas and throw themselves on the beach and have to be carried away by the police.”

Emotions run high on the subject of cetaceans (the scientific name for the suborder of whales and dolphins).

Perhaps it's a sense of collective guilt — our relationship with these animals has been bloody ever since the first harpoon was thrown.

Reconciling centuries of whaling with a few decades of whale-loving isn't easy.

Having spent eight years watching and writing about whales, I've come to the conclusion that our shared history is destined to remain troubled.

Now new evidence has emerged to underline that conviction.

In the award-winning documentary, The Cove, which stunned audiences at this year's Sundance Festival, and is due for release later this summer, director Louie Psihoyos uses covert filming to uncover Japan's dirty little secret: the annual slaughter of 23,000 dolphins.

In whale terms, Japan has long been a pariah. It exploits a loophole in the 1986 international moratorium on whaling to carry on “scientific research” in the Pacific and Southern Oceans.

Sailing into areas officially declared as whale sanctuaries, its fleet catches thousands of minke and fin whales each year.

Grenades are shot into the crania of their prey; some animals may take hours to die. Rather than furnishing data for scientific experiments, they end up as whale sushi and whale burgers.

Last year, the Japanese proposed to start hunting humpbacks. These are exquisite animals.

I've been watching them in the waters off Cape Cod for years and never fail to be amazed at their beauty and amused at their antics.

It is impossible not to smile when a 50-ton, 50-foot whale launches itself out of the water before your eyes.

Selecting these crowd-pleasers as their latest target was a provocative act; the Japanese must have known it would arouse the ire of the eco-warriors of Sea Shepherd.

Under the command of their Canadian captain, Paul Watson, and funded by well-wishers (including the rock group the Red Hot Chili Peppers), these cetacean avengers have put themselves on the front line of the “whale wars”.

Last year, two of their crew were accused of piracy when they boarded a whale-catcher to deliver their protest in person.

The Japanese call them terrorists, others see them as heroes.

The Cove is set to raise the temperature of an already heated debate to new highs.

Unlike its whaling fleet sailing in remote seas, the Japanese dolphin harvest is carried out on its coastline, within sight of its citizens.

Aware of the negative publicity, the authorities erect huge blue tarpaulin screens across narrow inlets to prevent filming as dolphins are driven to their deaths.

Nevertheless, The Cove has managed to sneak through this curtain of shame. What it reveals is horrifying.

Most of the mammals killed are destined for human consumption, misleadingly labelled as whale meat (rather than dolphin). But some are taken alive.

Only animals which show the most defiance — by leaping highest — are spared for sale to dolphinaria.

It is an inexcusable trade, and I urge anyone who cares about these animals to protest to the Japanese government.

Yet there are other factors to consider in this issue of inter-species morality.

Apart from the fact that whaling continues in Norway, where whale-watching tourists have been aghast to see the very animals they are observing being harpooned by whalers, Europe also hosts its own little-known whale cull.

In the Faroes — North Sea islands under Danish and therefore EU jurisdiction — up to 1,000 pilot whales are slaughtered each year during the grindadrĂ¡p, a communal hunt that dates back to the islanders' Viking roots.

Pilot whales are named for their propensity to follow a leader, a loyalty that their human pursuers exploit.

Pods of whales are forced into shallow waters which turn red with blood as the animals' necks are severed with sharp knives.

Their meat is then divided up among the islanders; young children wander the harbourside carrying bleeding chunks of whale in carrier bags. (In November 2008, Faroese authorities declared the meat inedible, due to the intake of toxic PCBs. Much of Japanese whale meat may be similarly contaminated.)

In the Faroes, as in Japan, the defence is that these are long-held traditions.

The Japanese counter that in North America, the Inuit are allowed to hunt bowhead whales, far rarer than their own prey. They have a point.

Bowheads are the longest-living animals on earth: in the 1990s, Bowheads were found to have 200-year-old Inuit harpoons imbedded in their blubber, making the animals themselves even older.

There are other historical considerations. At the end of the Second World War, after the atomic bombs had fallen on Hiroshima and Nagasaki, the decommissioned Japanese navy was converted into a whaling fleet by the Allied powers, so the defeated and starving nation could feed itself.

Since Japan was encouraged and even assisted in whaling by the West — whale was served in schools until the 1970s — it irks to be lectured on the subject.

“It's not because Japanese want to eat whale meat,” Ayako Okubo of the Ocean Policy Research Foundation told theNew York Times recently.

“It's because they don't like being told not to eat it by foreigners.”

Indeed, some Americans contest that it was their own over-use of pressure and the moral weight of the environmental lobby that pushed Japan into its stubborn position.

At next week's annual meeting of the International Whaling Commission in Madeira, pragmatic conservationists will argue that the Japanese should be allowed to take minke whales (numerous enough for their hunters to call them “cockroaches of the sea”) in their own waters, thereby relieving the pressure of their unrestricted whaling in the Southern Ocean.

Japan has already signalled its disapproval of the idea; a new battle looms.

Meanwhile, the West congratulates itself on having banned whaling long ago.

Yet if it wasn't for the fact that America, which pioneered modern whaling in the 18th century, had given up the industry for entirely commercial reasons at the beginning of the 20th century, there would have been no international moratorium.

By then, whales had outlived their uses for the burgeoning American empire, which no longer needed whale oil to light its cities and lubricate its industries.

Its attentions had fixed on mineral oil, discovered in Pennsylvania in 1859, and all the attendant geo-political strife it caused.

Yet whales were even conscripted into those global wars.

Nitroglycerine derived from whales was used in explosives in the First World War.

Trench foot was treated using whale oil. Later, nuclear submarines were designed to the hydrodynamics demonstrated by whales, themselves natural sub–marines: sperm whales can dive for two miles and stay down for up to two hours in their search for squid.

Even the space race found a use for whales. Sperm whale oil does not freeze in sub-zero temperatures, making it perfect for use by Nasa.

As I write this, the space probe Voyager and the Hubble telescope are spinning in space, lubricated by whales.

Killer whales and dolphins were trained by the military to plant underwater mines.

In Vietnam, dolphins were employed as assassins, injecting enemy divers with lethal doses of carbon dioxide.

Dolphins were also used in both Gulf Wars — to what extent, or in what capacity, remains an official secret.

Britain cannot claim innocence on this score. We were still a whaling nation in the 1960s. Up until the mid-19th century, London itself was a whaling port.

At Greenwich and Rotherhithe, on quays now overlooked by modern apartment blocks, bits of whale brought back from Greenland once lay.

The site of the Millennium Dome was a whale-rendering plant — tactfully situated out of olfactory range of the capital.

London's whaling past is also remembered in Whalebone Lane, Dagenham, once the site of an arch constructed from the jawbones of a Right whale that foundered in the Thames in 1658 and which was promptly slaughtered.

Other cetacean visitors to London have been little better treated.

In 1793, a 30-foot killer whale found itself subject of “an exciting chase” after it was harpooned, towing its hunters at speed up and down the Thames.

In 1842, a minke whale dawdling off Deptford was set upon by five sailors.

Armed with a “large bearded spear”, they attacked “the monster”, which “soon showed symptoms of weakness, and threw up large quantities of water from the blowing apertures on its back”. Its carcase ended up on display outside a butcher's shop.

Nineteenth-century London was fond of such sensation.

In 1831, a giant wooden hut was erected in Trafalgar Square, wherein the skeleton of a massive blue whale was set up, to the delight of Londoners who paid a shilling to quaff wine while wandering within the leviathan's ribs.

In 1864, an entire preserved fin whale was exhibited in a shed in Shoreditch behind Liverpool Street station.

And at the Royal Aquarium in Westminster in 1877, a live beluga whale captured off Labrador languished in an iron tank measuring just six feet deep.

Even then it was clear that these were not exactly ideal conditions.

Thomas Claughton, the controversial Bishop of St Albans, complained the whale was “the creature of which the Psalmist speaks as placed in its element by the Great Creator”; it was not man's right to take him out of it.

The Times correctly predicted the hapless mammal's demise, adding: “Should he succumb to the unfavourable conditions of life in this city, his coat will make porpoise-skin boots.”

Even more extraordinary was the fact that a dolphin stranded at Battersea Bridge in 1918 was summarily eaten by the Natural History Museum's staff and their “distinguished correspondents” at a Mansion House banquet.

“The opinions received afterwards were nearly all favourable, and some of them enthusiastic,” reported Professor Sidney Harmer.

Contrast such historical fates with that of the whale which swam up the Thames in January 2006.

As the whale, a Northern Bottlenose, grew weak from stress and dehydration, its plight garnered international media coverage.

Its final passing, borne down river on a rubber bier, was greeted with the kind of solemnity accorded to a head of state.

Now its skeleton lies in the Natural History Museum — along with its amputated dorsal fin squashed into a glass jar.

Perhaps most surreal of all the capital's whalish tales, however, is that of the dolphins of Oxford Street.

In 1971 the London Dolphinarium, a bizarre striptease club, opened at 65 Oxford Street, complete with scantily-clad “aquamaids”.

Remnants of its blue-painted tank can still be seen in a cellar off Soho Square.

The dolphinarium was run by a company called Pleasureama, whose “sole object”, announced its chairman, Sir Harmar Nicholls, MP, was “to make a profit for its shareholders”.

It lasted less than two years. Nevertheless, in 1974 Paul Raymond opened a Soho revue for which dolphins were trained to undo showgirls' bras.

Protests closed it down after six weeks. Not even world-weary Londoners could countenance such an outrage in the new age of “Save the Whale”.

They might be surprised to learn that 40 years later that time has come again.

source:www.thisislondon.co.uk

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Video on Return of the Whale hunters